Table 13 sustained virological response based on genotype and pre-treatment viral load after copegus combination therapy with peginterferon alfa-2a in hiv-hcv co-infected patients.
Find out about Copegus.
The dose of COPEGUS should not be further modified in patients with renal impairment. If severe adverse reactions or laboratory abnormalities develop.COPEGUS should be discontinued.if appropriate.until the adverse reactions abate or decrease in severity. If intolerance persists after restarting COPEGUS.COPEGUS/PEGASYS therapy should be discontinued.
Dyspnea.pulmonary infiltrates.pneumonitis.pulmonary hypertension.and pneumonia have been reported during therapy with ribavirin and interferon. Occasional cases of fatal pneumonia have occurred. In addition.sarcoidosis or the exacerbation of sarcoidosis has been reported. If there is evidence of pulmonary infiltrates or pulmonary function impairment.patients should be closely monitored and.if appropriate.combination COPEGUS/PEGASYS treatment should be discontinued.
Copegus should be taken with food. Copegus should be given in combination with PEGASYS. it is important to note that Copegus should never be given as monotherapy. See PEGASYS Package Insert for all instructions regarding PEGASYS dosing and administration.
The following severe side effects are associated in particular with Copegus use in combination with interferon alfa-2a or peginterferon alfa-2a.please refer to the package leaflet of these medicinal products for more detailed information on these safety issues.
Ribavirin produced significant embryocidal and/or teratogenic effects in all animal species in which adequate studies have been conducted. Malformations of the skull.palate.eye.jaw.limbs.skeleton.and gastrointestinal tract were noted. The incidence and severity of teratogenic effects increased with escalation of the drug dose. Survival of fetuses and offspring was reduced [see Contraindications (4) and Warnings and Precautions (5.1)] .
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copegus is also incorporated into the viral genome causing lethal mutagenesis and a subsequent decrease in specific viral infectivity.
