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The precise mechanism of action of Lioresal is not fully known. Lioresal is capable of inhibiting both monosynaptic and polysynaptic reflexes order lioresal medication the spinal level.possibly by hyperpolarization of afferent terminals.although actions at supraspinal sites may also occur and contribute to its clinical effect. Although Lioresal is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA).there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals.Lioresal has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance.somnolence.ataxia.and respiratory and cardiovascular depression. Lioresal is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent.being reduced with increasing doses. Lioresal is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.
Once you start taking baclofen.don’t stop taking it suddenly on your own. If you need to stop.your doctor will lower your dose gradually.
Abrupt discontinuation of oral baclofen may cause seizures and hallucinations. Abrupt discontinuation of intrathecal baclofen may result in.
This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive.use machinery.or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana.
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