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A. Glucotrol (glipizide) is an anti-diabetic drug from the sulfonylurea class used in the treatment of type II diabetes. The most common side effects of Glucotrol include asthenia.headache.dizziness.nervousness.tremor.diarrhea.and flatulence. Glucophage (metformin) are used to treat type 2 diabetes. Glucophage (metformin) helps control blood sugar in a number of ways. These include helping the body respond better to the insulin it makes naturally.decreasing the amount of sugar the liver makes.and decreasing the amount of sugar the intestines absorb. Common side effects of Glucophage include diarrhea.nausea.and upset stomach Glipizide and metformin work by two different mechanisms and therefore the doses are not interchangeable. Thus.there is no dose of glipizide that is equivalent to metformin since each works differently within the body. If you are trying to switch between medications.your doctor should be able to determine the correct dosing for you based on your current blood glucose levels and/or A1c levels. Megan Uehara.PharmD.
Clinical studies have not found conclusive evidence that anti-diabetic drugs reduce macrovascular risk.
The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents.some azoles.and other drugs that are highly protein bound.salicylates.sulfonamides.chloramphenicol.probenecid.coumarins.monoamine oxidase inhibitors.quinolones and beta adrenergic blocking agents. conversely.certain drugs tend to produce hyperglycemia and may lead to loss of control.including thiazides and other diuretics.corticosteroids.phenothiazines.thyroid order glucotrol medication.estrogens.oral contraceptives.phenytoin.nicotinic acid.sympathomimetics.calcium channel order glucotrol medication drugs.and isoniazid. when coadministering glipizide with such drugs.patient should be observed closely for hypoglycemia or hyperglycemia. when such drugs are withdrawn.observe patient closely for loss of control.
B. May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
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